Protein Details: Gamma-aminobutyric acid receptor subunit rho-2

Function

Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA); the major inhibitory neurotransmitter in the brain (By similarity). Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of rho subunits; where GABA molecules bind at the rho intersubunit interfaces (By similarity). When activated by GABA; rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Rho-2 GABAARs may contribute to the regulation of glial development in the cerebellum by controlling extrasynaptic transmission. Rho-2 GABAARs are also involved in neuronal tonic (extrasynaptic) and phasic (synaptic) transmission in the Purkinje neurons of the cerebellum. Rho-2 GABAARs expressed in retina may play a role in retinal neurotransmission (By similarity).

Sequence

PDB Structures

Ligand Binding